A Secret Weapon For https://www.ceesdekker.net
A Secret Weapon For https://www.ceesdekker.net
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Human Rad51 filaments on double- and solitary-stranded DNA: correlating frequent and irregular types with recombination purpose.
Multicolor imaging of your bacterial nucleoid and mobile division proteins with blue, orange, and around-infrared fluorescent proteins
Because 2000, Dekker has shifted the principle focus of his perform toward biophysics where he scientific studies the Houses of single biomolecules and cells using the equipment of nanotechnology. This alteration of area was driven by his fascination to the remarkable operating of Organic molecular structures, along with with the very long-term perspective that lots of appealing discoveries is usually expected On this discipline.[5] Latest strains of investigate in his biophysics team are in the parts of:[six]
2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and first at any time study of your dynamics DNA supercoils and the discovery of supercoil hopping
Immediate immobilization of native yeast iso-one cytochrome c on bare gold: quick electron relay to redox enzymes and zeptomole protein-movie voltammetry
MATLAB codes for information processing are offered at . Julia codes employed for numerical simulation can be found at .
Atomic drive microscopy shows that vaccinia topoisomerase IB generates filaments on DNA in the cooperative manner
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Resolving the action dimensions in condensin-pushed DNA loop extrusion identifies ATP binding since the phase-creating method
In 1993 he was appointed as Associate Professor at Delft University of Know-how. In the mid-1990s Dekker and his crew obtained achievement with the discovery with the electronic Homes of carbon nanotubes, the 1st one-molecule transistor as well as other nanoscience.
Quite a few new phenomena have been discovered, and he and his exploration group recognized a leading situation On this industry of investigation. Dekker and his study team discovered new physics of nanotubes together with explored the feasibility of molecular electronics. In 1998, they had been the 1st to construct a transistor based upon just one nanotube molecule.
For example, we think about the nucleopore intricate, a gateway among the mobile nucleus plus the cytoplasm. This is an extremely complicated procedure and for that reason tough to study in a very cell, so we use ceesdekker biomimetics. We reconstruct holes and then insert particular person factors of the nucleopore elaborate to review transportation by means of it at the single-molecule stage.’
Illustration (2) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is shown in grey, the rim of the pore is highlighted in purple, and a 3D rendering on the motion on the DNA rod is displayed.